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Depletion of γ/δ T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis by Carme Pelegrí; Petra Kühnlein; Eberhard Buchner; Carsten B. Schmidt; Angels Franch; Margarida Castell; Thomas Hünig; Frank Emmrich; Raimund W. Kinne is a Medicine article available to read on EtoBox.

What is Depletion of γ/δ T cells does not prevent or ameliorate, but rather aggravates, rat adjuvant arthritis about?

Objective. To investigate the role of $6 T cells in Mycobacterium tuberculosk-induced rat adjuvant arthritis. Methods. Rats with adjuvant arthritis were injected With the anti-T cell receptor $6 (anti-TCRy'S) monoclonal antibody V65 according to a preventive protocol, a pre-arthritis peak protocol, and a late therapeutic protocol. Arthritis severity and joint destruction were monitored, and depletion of target cells was analyzed by flow cytometry. Results. Although all protocols led to successful depletion of TCRy'$''@" cells in peripheral blood and lymph nodes, none of the regimens influenced clinical parameters of adjuvant arthritis. If rats were treated before the clinical peak of adjuvant arthritis, however, joint destruction was significantly more severe than in vehicle-treated rats. Conclusion. Rat adjuvant arthritis is not promoted or perpetuated by y'S T cells. Aggravation of joint destruction with pre-arthritis peak anti-$6 treatment suggests a stage-dependent protective role of y's T cells in adjuvant arthritis.

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Author

Carme Pelegrí; Petra Kühnlein; Eberhard Buchner; Carsten B. Schmidt; Angels Franch; Margarida Castell; Thomas Hünig; Frank Emmrich; Raimund W. Kinne

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

1996

Language

EN

Field

Medicine (Health Sciences)