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Role of Exosomes in Dermal Wound Healing: A Systematic Review by Anesh Prasai; Jayson W. Jay; Daniel Jupiter; Steven E. Wolf; Amina El Ayadi is a Medicine article available to read on EtoBox.

What is Role of Exosomes in Dermal Wound Healing: A Systematic Review about?

Cell-based therapy imparts its therapeutic effects through soluble GFs and vesicular bodies such as exosomes. A systematic review with a meta-analysis of preclinical studies was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the modified Stroke Therapy Academic Industry Roundtable guidelines to identify exosomes as an archetype biological therapy for dermal wound healing and to provide guidelines for the concentrations to be used in preclinical studies. A total of 51 rodent studies were included in the systematic review and 9 were included in the meta-analysis section. Three independent reviewers cross-screened eligibility and selected studies for quality assessment from 3,064 published studies on exosomes and wound healing. The mean quality scores for all studies were 5.08 ± 0.752 and 5.11 ± 1.13 for systematic review and meta-analysis, respectively. Exosome effects were reported to have the highest efficacy at 7 days (OR = 1.82, 95% confidence interval = 0.69‒2.95) than at 14 days (OR = 2.29, 95% confidence interval = 0.01‒4.56) after administration. Exosomes were reported to regulate all phases of skin wound healing, mostly by t

Who reads Role of Exosomes in Dermal Wound Healing: A Systematic Review?

Author

Anesh Prasai; Jayson W. Jay; Daniel Jupiter; Steven E. Wolf; Amina El Ayadi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)