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Reducing or eliminating use of the category of atypical squamous cells of undetermined significance decreases the diagnostic accuracy of the Papanicolaou smear by Martha B. Pitman; Edmund S. Cibas; Celeste N. Powers; Andrew A. Renshaw; William J. Frable is a Medicine article available to read on EtoBox.
What is Reducing or eliminating use of the category of atypical squamous cells of undetermined significance decreases the diagnostic accuracy of the Papanicolaou smear about?
## Background: The diagnosis of "atypical squamous cells of undetermined significance" (ascus) is controversial, not only for the clinical utility of its subcategories (favor reactive vs. favor dysplasia), but for its very existence as an expression of uncertainty. in the current study, the authors investigated the impact of reducing and eliminating this category on the sensitivity and predictive values for detecting squamous intraepithelial lesions (sils). ## Methods: One hundred cervical papanicolaou (pap) smears originally diagnosed as ascus, all of which had histologic follow-up, were reviewed blindly and reclassified as either negative (within normal limits/benign cellular changes), low-grade sil (lsil), or high-grade sil (hsil) by 1 reviewer who eliminated ascus as a diagnostic possibility entirely. a second reviewer reinterpreted the cases but attempted to use the ascus diagnosis (favor reactive or favor dysplasia) sparingly. all histologic diagnoses were reviewed, and an adjudicated final diagnosis was established. reviewed smear interpretations were correlated with the histologic diagnosis (original, reviewed, and adjudicated). statistical analysis was performed using the
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- Author
- Martha B. Pitman; Edmund S. Cibas; Celeste N. Powers; Andrew A. Renshaw; William J. Frable
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)