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Can I read Inflammation Status Modulates the Effect of Host Genetic Variation on Intestinal Gene Expression in Inflammatory Bowel Disease on EtoBox?

Inflammation Status Modulates the Effect of Host Genetic Variation on Intestinal Gene Expression in Inflammatory Bowel Disease by Hu, Shixian (author);Uniken Venema, Werna T. (author);Westra, Harm-Jan (author);Vich Vila, Arnau (author);Barbieri, Ruggero (author);Voskuil, Michiel D. (author);Blokzijl, Tjasso (author);Jansen, Bernadien H. (author);Li, Yanni (author);Daly, Mark J. (author);Xavier, Ramnik J. (author);Dijkstra, Gerard (author);Festen, Eleonora A. (author);Weersma, Rinse K. (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Inflammation Status Modulates the Effect of Host Genetic Variation on Intestinal Gene Expression in Inflammatory Bowel Disease about?

## Abstract More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to disease development in involved tissue. Here, we hypothesized that host genetic variation affects gene expression in an inflammation-dependent way, and investigated 299 snap-frozen intestinal biopsies from inflamed and non-inflamed mucosa from 171 IBD patients. RNA-sequencing was performed, and genotypes were determined using whole exome sequencing and genome wide genotyping. In total, 28,746 genes and 6,894,979 SNPs were included. Linear mixed models identified 8,881 independent intestinal cis-expression quantitative trait loci (cis-eQTLs) (FDR < 0.05) and interaction analysis revealed 190 inflammation-dependent intestinal cis-eQTLs (FDR < 0.05), including known IBD-risk genes and genes encoding immune-cell receptors and antibodies. The inflammation-dependent cis-eQTL SNPs (eSNPs) mainly interact with prevalence of immune cell types. Inflammation-dependent intestinal cis-eQTLs reveal genetic susceptibility under inflammatory conditions that can help identify the cell types involved in and the pathways underlying inflammation, know

Who reads Inflammation Status Modulates the Effect of Host Genetic Variation on Intestinal Gene Expression in Inflammatory Bowel Disease?

It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.

Author
Hu, Shixian (author);Uniken Venema, Werna T. (author);Westra, Harm-Jan (author);Vich Vila, Arnau (author);Barbieri, Ruggero (author);Voskuil, Michiel D. (author);Blokzijl, Tjasso (author);Jansen, Bernadien H. (author);Li, Yanni (author);Daly, Mark J. (author);Xavier, Ramnik J. (author);Dijkstra, Gerard (author);Festen, Eleonora A. (author);Weersma, Rinse K. (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Biochemistry, Genetics and Molecular Biology (Life Sciences)

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