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Antiviral memory B cells exhibit enhanced innate immune response facilitated by epigenetic memory by Xiping Zhu; Sheng Hong; Jiachen Bu; Yingping Liu; Can Liu; Runhan Li; Tiantian Zhang; Zhuqiang Zhang; Liping Li; Xuyu Zhou; Zhaolin Hua; Bing Zhu; Baidong Hou is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The long-lasting humoral immunity induced by viral infections or vaccinations depends on memory B cells with greatly increased affinity to viral antigens, which are evolved from germinal center (GC) responses. However, it is unclear whether antiviral memory B cells represent a distinct subset among the highly heterogeneous memory B cell population. Here, we examined memory B cells induced by a virus-mimicking antigen at both transcriptome and epigenetic levels and found unexpectedly that antiviral memory B cells exhibit an enhanced innate immune response, which appeared to be facilitated by the epigenetic memory that is established through the memory B cell development. In addition, T-bet is associated with the altered chromatin architecture and is required for the formation of the antiviral memory B cells. Thus, antiviral memory B cells are distinct from other GC-derived memory B cells in both physiological functions and epigenetic landmarks.

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Author

Xiping Zhu; Sheng Hong; Jiachen Bu; Yingping Liu; Can Liu; Runhan Li; Tiantian Zhang; Zhuqiang Zhang; Liping Li; Xuyu Zhou; Zhaolin Hua; Bing Zhu; Baidong Hou

Publisher

American Association for the Advancement of Science

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)