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Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23) by Laurence Dahéron; Anne Veinstein; Françoise Brizard; Harry Drabkin; Laurence Lacotte; François Guilhot; Christian Jacques Larsen; André Brizard; Joelle Roche is a Medicine article available to read on EtoBox.

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## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosomal translocation in a patient who developed AML‐M5 3 years after treatment for a follicular lymphoma. Through inverse PCR, the __LPP__ (lipoma preferred partner) gene on 3q28 was identified as the __MLL__ fusion partner. LPP contains substantial identity to the focal adhesion protein, zyxin, and is frequently fused to __HMGIC__ in lipomas. The breakpoint occurred in intron 8 of __MLL__ and __LPP__. Two in‐frame __MLL‐LPP__ transcripts, which fuse __MLL__ exon 8 to __LPP__ exon 9, were detected by RT‐PCR, although the smaller of these contained a deletion of 120 bp from the __MLL__ sequence. The predicted MLL‐LPP fusion protein includes the A/T hook motifs and methyltransferase domain of MLL joined to the two last LIM domains of LPP. A reciprocal __LPP‐MLL__ transcript, predicted to include the proline‐rich and leucine zipper motifs, and the first LIM domain of LPP were also detected by RT

Who reads Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23)?

Author

Laurence Dahéron; Anne Veinstein; Françoise Brizard; Harry Drabkin; Laurence Lacotte; François Guilhot; Christian Jacques Larsen; André Brizard; Joelle Roche

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2001

Language

EN

Field

Medicine (Life Sciences)