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Kinetic Signature of Cooperativity in the Irreversible Collapse of a Polymer by Scolari, Vittore F.; Mercy, Guillaume; Koszul, Romain; Lesne, Annick; Mozziconacci, Julien is a scholarly article available to read on EtoBox.

What is Kinetic Signature of Cooperativity in the Irreversible Collapse of a Polymer about?

We investigate the kinetics of a polymer collapse due to the formation of irreversible crosslinks between its monomers. Using the contact probability $P(s)$ as a scale-dependent order parameter depending on the chemical distance $s$, our simulations show the emergence of a cooperative pearling instability. Namely, the polymer undergoes a sharp conformational transition to a set of absorbing states characterized by a length scale $\xi$ corresponding to the mean pearl size. This length and the transition time depend on the polymer equilibrium dynamics and the crosslinking rate. We confirm experimentally this transition using a DNA conformation capture experiment in yeast.

Author

Scolari, Vittore F.; Mercy, Guillaume; Koszul, Romain; Lesne, Annick; Mozziconacci, Julien

Published

2018

Language

EN