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Sex-stratified Gene-by-environment Genome-wide Interaction Study of Trauma, Posttraumatic-stress, and Suicidality by Wendt, Frank R. (author);Pathak, Gita A. (author);Levey, Daniel F. (author);Nuñez, Yaira Z. (author);Overstreet, Cassie (author);Tyrrell, Chelsea (author);Adhikari, Keyrun (author);De Angelis, Flavio (author);Tylee, Daniel S. (author);Goswami, Aranyak (author);Krystal, John H. (author);Abdallah, Chadi G. (author);Stein, Murray B. (author);Kranzler, Henry R. (author);Gelernter, Joel (author);Polimanti, Renato (author) is a Neuroscience article available to read on EtoBox.

What is Sex-stratified Gene-by-environment Genome-wide Interaction Study of Trauma, Posttraumatic-stress, and Suicidality about?

Epidemiologic studies recognize that trauma and posttraumatic stress are associated with heightened suicidal behavior severity, yet examination of these associations from a genetic perspective is limited. We performed a multivariate gene-by-environment genome-wide interaction study (GEWIS) of suicidality in 123,633 individuals using a covariance matrix based on 26 environments related to traumatic experiences, posttraumatic stress, social support, and socioeconomic status. We discovered five suicidality risk loci, including the male-associated rs2367967 (), which replicated in an independent cohort. All GEWIS-significant loci exhibited interaction effects where at least 5% of the sample had environmental profiles conferring opposite SNP effects from the majority. We identified PTSD as a primary driving environment for GxE at suicidality risk loci. The male suicidality GEWIS was enriched for three middle-temporal-gyrus inhibitory neuron transcriptomic profiles: - and -expressing cells ( = 0.028, = 3.74 × 10), -expressing cells ( = 0.030, = 0.001), and -expressing cells ( = 0.029, = 9.80 × 10). Combined with gene-based analyses ( = 2.38 × 10, = 1.51 × 10; = 2.04 × 10, = 7.76 ×

Who reads Sex-stratified Gene-by-environment Genome-wide Interaction Study of Trauma, Posttraumatic-stress, and Suicidality?

It is typically read by researchers, students, and practitioners in Neuroscience.

Author
Wendt, Frank R. (author);Pathak, Gita A. (author);Levey, Daniel F. (author);Nuñez, Yaira Z. (author);Overstreet, Cassie (author);Tyrrell, Chelsea (author);Adhikari, Keyrun (author);De Angelis, Flavio (author);Tylee, Daniel S. (author);Goswami, Aranyak (author);Krystal, John H. (author);Abdallah, Chadi G. (author);Stein, Murray B. (author);Kranzler, Henry R. (author);Gelernter, Joel (author);Polimanti, Renato (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Neuroscience (Life Sciences)

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