Can I read Echocardiographic Molecular Imaging Of The Effect Of Anti-cytokine Therapy For Atherosclerosis on EtoBox?
Echocardiographic Molecular Imaging Of The Effect Of Anti-cytokine Therapy For Atherosclerosis by Shentu, Weihui; Ozawa, Koya; Nguyen, TheAnh; Wu, Melinda D.; Packwood, William; Xie, Aris; Muller, Matthew A.; Brown, Eran; Hagen, Matthew W.; López, José A.; Lindner, Jonathan R. is a Medicine article available to read on EtoBox.
What is Echocardiographic Molecular Imaging Of The Effect Of Anti-cytokine Therapy For Atherosclerosis about?
## Background: Echocardiographic molecular imaging techniques are beginning to be applied to evaluate preclinical efficacy of new drugs. in a large clinical trial, anti-interleukin-1β (il-1β) immunotherapy reduced atherosclerotic events, yet treatment effects were modest, and the mechanisms of action were not fully elucidated. we tested the hypothesis that echocardiographic molecular imaging can assess changes in vascular thromboinflammatory status in response to anti-il-1β therapy. ## Methods: In wild-type and atherosclerotic mice deficient for the low-density lipoprotein-receptor and apobec-1, closed-chest myocardial infarction (mi) was performed to mimic high-risk clinical cohorts. control animals had sham surgery. post-mi animals were randomized to either no therapy or anti-il-1β immunotherapy, which was continued weekly. at post-mi day 3 or 21, in vivo ultrasound molecular imaging of aortic vcam-1, p-selectin, von willebrand factor a1-domain, and platelet gpibα in the thoracic aorta was performed. aortic histology and nf-κb activity were assessed in atherosclerotic mice. ## Results: In both atherosclerotic and wild-type mice, mi produced a several-fold increase (p < .05) in ao
Who reads Echocardiographic Molecular Imaging Of The Effect Of Anti-cytokine Therapy For Atherosclerosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shentu, Weihui; Ozawa, Koya; Nguyen, TheAnh; Wu, Melinda D.; Packwood, William; Xie, Aris; Muller, Matthew A.; Brown, Eran; Hagen, Matthew W.; López, José A.; Lindner, Jonathan R.
- Publisher
- Elsevier Science; Elsevier ; C.V. Mosby Company; Elsevier BV (ISSN 1097-6795)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)