Opening book details…
Can I read Expression of the Tyrosine Kinase C‐kit Is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer on EtoBox?
Expression of the Tyrosine Kinase C‐kit Is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer by Ulrich‐Peter Rohr; Nina Rehfeld; Lucy Pflugfelder; Helene Geddert; Wolfram Müller; Ulrich Steidl; Roland Fenk; Thorsten Gräf; Matthias Schott; Klaus‐Peter Thiele; Helmut Erich Gabbert; Ulrich Germing; Ralf Kronenwett; Rainer Haas is a Medicine article available to read on EtoBox.
What is Expression of the Tyrosine Kinase C‐kit Is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer about?
## Abstract In a retrospective analysis of 203 patients with small cell lung cancer (SCLC), we examined the prognostic value of c‐kit expression on survival. Expression of c‐kit was examined immunohistochemically in formalin‐fixed, paraffin‐embedded tissue sections. c‐kit was observed in 87.7% of SCLC tumors. Using the Kaplan‐Meier model, we found that lack of c‐kit expression was associated with significantly shorter survival time compared to the presence of c‐kit expression (mean survival 151 ± 27 __vs__. 358 ± 49 days, __p__ = 0.0084). Moreover, the proportion of c‐kit^+^ cells within the tumor was also related to survival time. Patients with tumors in which >75% of cells stained positive for c‐kit had a mean overall survival time of 424 (±72) compared to 295 (±67) days for patients with 25–75% c‐kit^+^ tumor cells. Patients with tumors containing <25% c‐kit^+^ cells had the worst survival, with 164 (±24) days (__p__ = 0.0033). Further parameters associated with short survival times were low performance status, elevated levels of lactate dehydrogenase and higher stage according to the TNM classification. Multivariate analysis using the Cox regression model showed that the propor
Who reads Expression of the Tyrosine Kinase C‐kit Is an Independent Prognostic Factor in Patients with Small Cell Lung Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ulrich‐Peter Rohr; Nina Rehfeld; Lucy Pflugfelder; Helene Geddert; Wolfram Müller; Ulrich Steidl; Roland Fenk; Thorsten Gräf; Matthias Schott; Klaus‐Peter Thiele; Helmut Erich Gabbert; Ulrich Germing; Ralf Kronenwett; Rainer Haas
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)