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Low Endothelial Shear Stress Is Associated with Increased Coronary Atherosclerotic Plaque Activity in Patients That Presented with Acute Coronary Syndrome by Jonathan K. Tapley & Barry J. Doyle & Jamie W. Bellinge & Harrison T. Caddy & Dirk C. Blom & Thomas Churack & David E. Newby & Carl J. Schultz & Lachlan J. Kelsey is a book available to read on EtoBox.

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Journal of Cardiovascular Computed Tomography, Corrected proof. doi:10.1016/j.jcct.2025.04.003ABSTRACTKeywords:Background: Both coronary atherosclerotic plaque activity and low endothelial shear stress (ESS) are predictive ofEndothelial shear stressadverse cardiovascular events. We aimed to investigate their association and relationship with high-risk plaqueComputational fluid dynamicsfeatures.Coronary atherosclerotic plaque activityMethods: Coronary computed tomography angiography (CCTA) based flow simulations were used to compute ESSPositron emission tomographyin patients presenting with acute coronary syndrome proceeding percutaneous coronary intervention. AssociaCoronary computed tomographic angiographytions between ESS, CCTA plaque features and coronary plaque activity, measured by 18F-sodium fluoride(18F–NaF) positron emission tomography (PET), were investigated at the coronary segment and vessel level.Results: ESS and coronary plaque activity were both analyzed in 330 coronary segments and 123 vessels. The areaof low ESS (<0.4 Pa), termed low shear area (LSA), was larger in 18F–NaF positive regions increasing from median11.7 mm2 (IQR: 4.6–27.4) to 29.0 mm2 (IQR: 14.1–55.2)

Author

Jonathan K. Tapley & Barry J. Doyle & Jamie W. Bellinge & Harrison T. Caddy & Dirk C. Blom & Thomas Churack & David E. Newby & Carl J. Schultz & Lachlan J. Kelsey

Publisher

x

Published

2025

Language

EN