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Surface Modification of Poly(tetramethylene Adipate-co-terephthalate) Membrane via Layer-by-layer Assembly of Chitosan and Dextran Sulfate Polyelectrolyte Multiplayer by Da-Guang Yu; Chi-Hsiung Jou; Wen-Ching Lin; Ming-Chien Yang is a Materials Science article available to read on EtoBox.

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The improvement of hydrophilicity and hemocompatibility of poly(tetramethylene adipate-co-terephthalate) (PTAT) membrane was developed via polyelectrolyte multilayers (PEMs) immobilization. The polysaccharide PEMs included chitosan (CS, as a positive-charged and antibacterial agent) and dextran sulfate (DS, as a negative-charged and anti-adhesive agent) were successfully prepared using the aminolyzed PTAT membrane in a layer-by-layer (LBL) self-assembly manner. The obtained results showed that the contact angle of as-modified PTAT membranes reached to the steady value after four bilayers of coating, hence suggesting that the full coverage was achieved. It could be found that the PTAT-PEMs membranes with DS as the outmost layer could resist the platelet adhesion and human plasma fibrinogen (HPF) adsorption, thereby prolonging effectively the blood coagulation times. According to L929 fibroblast cell growth inhibition index, the as-prepared PTAT membranes exhibited non-cytotoxic. Overall results demonstrated that such an easy, valid and shape-independent processing should be potential for surface modification of PTAT membrane in the application of hemodialysis devices.

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Author

Da-Guang Yu; Chi-Hsiung Jou; Wen-Ching Lin; Ming-Chien Yang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0927-7765)

Published

2007

Language

EN

Field

Materials Science (Physical Sciences)