Can I read Bridging Rapid and Sustained Antidepressant Effects of Ketamine on EtoBox?

Bridging Rapid and Sustained Antidepressant Effects of Ketamine by Ji-Woon Kim; Kanzo Suzuki; Ege T. Kavalali; Lisa M. Monteggia is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Bridging Rapid and Sustained Antidepressant Effects of Ketamine about?

Acute administration of (R,S)-ketamine (ketamine) produces rapid antidepressant effects that in some patients can be sustained for several days to more than a week. Ketamine blocks N-methyl-d-asparate (NMDA) receptors (NMDARs) to elicit specific downstream signaling that induces a novel form of synaptic plasticity in the hippocampus that has been linked to the rapid antidepressant action. These signaling events lead to subsequent downstream transcriptional changes that are involved in the sustained antidepressant effects. Here we review how ketamine triggers this intracellular signaling pathway to mediate synaptic plasticity which underlies the rapid antidepressant effects and links it to downstream signaling and the sustained antidepressant effects.

Who reads Bridging Rapid and Sustained Antidepressant Effects of Ketamine?

Author

Ji-Woon Kim; Kanzo Suzuki; Ege T. Kavalali; Lisa M. Monteggia

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)