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Nonrandomized Evaluation of Pelvic Lymph Node Irradiation in Localized Carcinoma of the Prostate by Carlos A. Perez; Jeff Michalski; Kathryn C. Brown; Mary Ann Lockett is a Medicine article available to read on EtoBox.

What is Nonrandomized Evaluation of Pelvic Lymph Node Irradiation in Localized Carcinoma of the Prostate about?

Purpose: A great deal of controversy exists regarding the potential benefit of pelvic lymph node irradiation compared with treatment to the prostate only in patients with localized prostate cancer. Despite numerous reports, including a randomized study, thii issue has not been completely elucidated. Methods and Materials: A total of %3 patients with histologically proven localized adenocarcinoma of the prostate treated with definitive radiation therapy alone were analyzed. Median follow-up was 6.5 years (minimum: 2 years, maximum: 22 years). Pelvic lymph nodes received 40 to 55 Gy with anteroposterior/posteroanterior and sometimes lateral stationary portals in 1.8 Gy daily fractions; an additional dose was delivered to the prostate with 120" bilateral arc rotation to complete doses of 65 to 68 Gy for Stage A2 and B tumors and 68 to 71 Gy for Stage C tumors. The same total doses were delivered with smaller fields when the prostate only was treated. Results: In Stage A2 (Tlb,c) the lo-year clinical pelvic failure rate was 16% regardless of the volume irradiated or tumor differentiation. With Stage B (T2) well-or moderately differentiated tumors, the lo-year pelvic failure rate-s were

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Author

Carlos A. Perez; Jeff Michalski; Kathryn C. Brown; Mary Ann Lockett

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1996

Language

EN

Field

Medicine (Health Sciences)