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Introduction: Men with non-metastatic castration-resistant prostate cancer (M0 CRPC) and rapidly rising prostate-specific antigen (PSA) are at high risk of developing metastatic (M1) CRPC. Enzalutamide (ENZA) improves overall survival (OS) and radiographic progression-free survival in men with M1 CRPC. We hypothesized that ENZA will improve metastasis-free survival (MFS) in men with M0 CRPC. Methods: Eligible men with M0 CRPC, PSA doubling time ≤10 months and PSA ≥2 ng/mL at screening continued androgen-deprivation therapy (ADT) and were randomized 2:1 to ENZA 160 mg or placebo. The primary endpoint was MFS. Secondary endpoints included time to PSA progression, time to first use of new antineoplastic therapy, OS, and safety. Results: In 1401 men, ENZA significantly prolonged median MFS (36.6 vs. 14.7 months; p<0.0001), median time to first use of new antineoplastic therapy (39.6 vs. 17.7 months p<0.0001), and median time to PSA progression (37.2 vs. 3.9 months; p<0.0001]) compared to placebo (Table 1; available at https://cua.guide/). In the first interim analysis of OS, there was a trend in favour of ENZA (hazard ratio [HR] 0.80; p=0.1519). Median duration of treatment was 18.4 vs

Who reads CUA Annual Meeting Abstracts 2018?

Author

CUAJ, Editorial

Publisher

Canadian Urological Association Journal; Canadian Medical Association/Association Medical Canadienne; Canadian Urological Association; Montréal: Canadian Urological Association, [2007]- (ISSN 1911-6470)

Published

2018

Language

EN

Field

Medicine (Health Sciences)