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A comparison of the toxic effects of 2-deoxy-D-glucose and 2-deoxy-2-fluoro-D-hexoses on Saccharomyces cerevisiae cells and protoplasts by Dr. P. Biely; L. P. Rjazanova; A. B. Tsiomenko is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The toxicity to the cells and protoplasts of __Saccharomyces cerevisiae__ of the sugar analogues modified at carbon 2 increases in the order 2‐deoxy‐D‐glucose (DG), 2‐deoxy‐2‐fluoro‐D‐glucose (FG) and 2‐deoxy‐2‐fluoro‐D‐mannose (FM). The fluorohexoses, similarly as DG, behave generally as analogues of both glucose and mannose, depending on the hexose used as a carbon source in the medium. Relative inhibitions of glucan and mannan synthesis in protoplasts were found to be dependent more on glucose and mannose used as the growth support than on the type of the sugar analogue. Certain degree of structural relationship of fluorohexoses to the corresponding natural hexoses was reflected in their effects on growth of intact cells. Growth on glucose was inhibited most effectively by FM, growth on mannose by FG. The data obtained support the view that the sugar analogues interfere mainly with the glucose‐mannose interconversion catalyzed by hexosephosphateisomerases. A comparison of the effects of fluorohexoses and DG on the synthesis of extracellular invertase and intracellular α‐glucosidase and alkaline phosphatase in protoplasts pointed to the fact that all three sugar analo

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Author

Dr. P. Biely; L. P. Rjazanova; A. B. Tsiomenko

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Akademie Verlag; Wiley (ISSN 0233-111X)

Published

1981

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)