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Functional heterogeneity of polymorphisms in the human organic anion transporter, OAT3 (SLC22A8) by A ERDMAN; C BROWN; R CASTRO; T TAYLOR; E CARLSON; K GIACOMINI is a Medicine article available to read on EtoBox.

What is Functional heterogeneity of polymorphisms in the human organic anion transporter, OAT3 (SLC22A8) about?

BACKGROUND/AIMS: SULT1A1 catalyzes the sulfate conjugation of estrogens and many drugs. A common ORF SNP (Arg213His, SULT1A1\*2) is associated with low SULT1A1 activity, and 2 additional SNPs, C(-624)G and G(-396)A, are associated with decreased transcription. ## METHODS: We examined the association of these 3 SNPs with breast cancer (BC) in 173 relatives of BC cases and 330 control subjects, and with percent mammographic density (PD) in 357 control postmenopausal women. RESULTS: Women with 2 copies of any one of the 3 SULT1A1 variant SNPs were at approximately 50% higher risk of breast cancer [for (Ϫ624) ORϭ1.7, CIϭ0.9 -3.1; for (Ϫ396) ORϭ1.6, CIϭ0.9 -2.8; for Arg213His ORϭ1.5, CIϭ0.8 -2.7]. Haplotype analysis showed increased risk of BC for those with all 3 SNPs (ORϭ 1.4, CIϭ0.9 -2.0). Significant increases in PD were also observed for carriers of the (Ϫ396) SNP [mean PDϭ18%, 20%, 23% for 0, 1, 2 copies, respectively, pϽ0.01]. CONCLUSIONS: These data suggest that intragene haplotype for SULT1A1 (Ϫ624)G, (Ϫ396)A and Arg213His may be associated with increased breast cancer risk, and the (Ϫ396) SNP with increased PD.

Who reads Functional heterogeneity of polymorphisms in the human organic anion transporter, OAT3 (SLC22A8)?

Author

A ERDMAN; C BROWN; R CASTRO; T TAYLOR; E CARLSON; K GIACOMINI

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2005

Language

EN

Field

Medicine (Health Sciences)