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There are multiple mass transfer steps involved in oxygen transfer from gas bubbles to cells in aerobic cultures. The largest resistance will be rate-controlling. For small bacteria or yeast cells, diffusion of oxygen through the liquid film surrounding gas bubbles is usually rate-determining. For large pellets or filaments, resistance through the liquid film around the particles can control. Effective mixing and aeration requires considering how fluid rheology, impeller type, and operating conditions like
- Author
- rubinanelofer
- Language
- EN