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What is Centrocortin about?

1) The cnnB4 mutation disrupts cleavage furrow assembly in Drosophila embryos despite normal centrosome localization and microtubule nucleating activity. 2) Centrocortin (CEN) binds to Centrosomin Motif 2 (CM2), a conserved domain in CNN required for cleavage furrow assembly. 3) The cnnB4 mutation, which lies within CM2, blocks CEN binding, revealing that CNN coordinates cleavage furrow formation by linking the centrosome to CEN through CM2.

Author

a4abhishekvyas

Language

EN