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Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO by O. Hunsicker; L. Materne; V. Bünger; A. Krannich; F. Balzer; C. Spies; R. C. Francis; S. Weber-Carstens; M. Menk; J. A. Graw is a Medicine article available to read on EtoBox.

What is Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO about?

## Abstract ## Background Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of two transfusion thresholds on short-term outcome in patients with ARDS. ## Methods Patients who received transfusions of RBCs were identified from a cohort of 1044 ARDS patients. After propensity score matching, patients transfused at a hemoglobin concentration of 8 g/dl or less (lower-threshold) were compared to patients transfused at a hemoglobin concentration of 10 g/dl or less (higher-threshold). The primary endpoint was 28-day mortality. Secondary endpoints included ECMO-free, ventilator-free, sedation-free, and organ dysfunction-free composites. ## Measurements and main results One hundred ninety-two patients were eligible for analysis of the matched cohort. Patients in the lower-threshold group had similar baseline characteristics and hemoglobin levels at ARDS onset but received fewer RBC units and had lower hemoglobin levels compared with the higher-threshold group during the course on the ICU (9.1 [IQR, 8.7–9.7] vs. 10.4 [10–11] g/dl, P < 0.001

Who reads Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO?

Author

O. Hunsicker; L. Materne; V. Bünger; A. Krannich; F. Balzer; C. Spies; R. C. Francis; S. Weber-Carstens; M. Menk; J. A. Graw

Publisher

Springer (Biomed Central Ltd.); BioMed Central; Springer Science and Business Media LLC; Research Square (ISSN 1466-609X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)