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Electrochemical immunosensing by carbon ink/carbon dot/ZnO-labeled-Ag@polypyrrole composite biomarker for CA-125 ovarian cancer detection by Nattinee Krathumkhet; Toyoko Imae; Fu-ming Wang; Chiou-Chung Yuan; Jusni Manidae Lumban Gaol; Nophawan Paradee is a Engineering article available to read on EtoBox.

What is Electrochemical immunosensing by carbon ink/carbon dot/ZnO-labeled-Ag@polypyrrole composite biomarker for CA-125 ovarian cancer detection about?

In this work, we demonstrated a novel cancer antigen 125 (CA125) biomarker detection based on electrochemical immunosensor. The biomarker on conductive composite materials of carbon ink/carbon dot/zine oxide (C-ink/CD/ZnO) was employed as an electrode platform by using ITO substrate to enhance the interaction of antibodies (Ab) with supporting catalytic performance of ZnO as a labeling signal molecule. They were a scientist attention for biosensor with chemical stability, strong biocompatibility, high conductive signal, and accuracy. Moreover, the nanocomposite of silver@polypyrrole (Ag@PPy) was used as a potential redox mediator. The labeled construction with Ag@PPy was more accuracy than that of a free-labeled. The created immunosensor was a wide linear range as 1 ag·mL−1 − 100 ng·mL−1 and a low limitation of detection as 0.1 fg·mL−1 under the optimal condition. This suggested that the immunosensor is considered to be an accurate and efficient diagnostic tool for CA125 and other biomarkers detection in actual sample analysis for clinic.

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Author

Nattinee Krathumkhet; Toyoko Imae; Fu-ming Wang; Chiou-Chung Yuan; Jusni Manidae Lumban Gaol; Nophawan Paradee

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)