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Community-driven Research in the Canadian Arctic: Dietary Exposure to Methylmercury and Gastric Health Outcomes by Emily V. Walker; Safwat Girgis; Yan Yuan; Karen J. Goodman is a Health Professions article available to read on EtoBox.

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## ABSTRACT Indigenous Arctic Canadians have a higher prevalence of gastric neoplasms relative to North Americans of European ancestry. We investigated the hypothesis that low-dose methylmercury exposure from eating fish/whale increases the risk of gastric cancer in Arctic communities. We used intermediate endpoints from an established model of gastric carcinogenesis: intestinal metaplasia, atrophy, and severe chronic gastritis. During 2008–2012, we obtained gastric biopsies from participants of community-driven projects in 3 communities. In 2016, we collected hair samples to measure methylmercury levels and interviewed them about diet. In cross-sectional analysis, logistic regression estimated odds ratios for the estimated effect of hair-methylmercury concentration on the prevalence of each pathology outcome stratified by selenium intake. Among 80 participants, prevalence of intestinal metaplasia, atrophy and severe chronic gastritis was 17, 29 and 38%, respectively. Adjusted Odds of severe chronic gastritis and atrophy were highest at hair-methylmercury concentrations ≥1μg/g when estimated selenium intake was 0, and approached 0 for all methylmercury levels as estimated selenium

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Author

Emily V. Walker; Safwat Girgis; Yan Yuan; Karen J. Goodman

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Health Professions (Health Sciences)