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Should embryos with autosomal monosomy by preimplantation genetic testing for aneuploidy be transferred?: Implications for embryo selection from a systematic literature review of autosomal monosomy survivors by M.E. Bunnell; L. Wilkins‐Haug; R. Reiss is a Medicine article available to read on EtoBox.

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## Abstract ## Objective To review the literature for survival and phenotypes of liveborns with autosomal monosomy to inform decisions regarding transfer of in vitro fertilization‐derived embryos reported as monosomic on preimplantation genetic testing for aneuploidy (PGT‐A). ## Method Ovid‐Medline and EMBASE were systematically searched to identify published case reports of liveborn individuals with autosomal monosomy, full or mosaic, for a whole chromosome. ## Results Fifty‐three reports describing 56 individuals with autosomal monosomy met the selection criteria: 1 case each of monosomy 14 and 16, 3 each for monosomy 15 and 18, 1 for group “E”, 5 for monosomy 20, 24 for monosomy 21, 7 for monosomy 22, and eleven for a “G” group chromosome. There were no reports with monosomy for the larger chromosomes 1 through 13, nor for chromosomes 17 or 19, autosomes with highest gene density. Most reported individuals had severe handicaps and died in infancy with some surviving longer. ## Conclusion Given potential for survival of handicapped individuals with autosomal monosomy for chromosomes 14, 15, 16, 18, 20, 21, and 22, low priority should be given to transfer of embryos apparently mon

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Author

M.E. Bunnell; L. Wilkins‐Haug; R. Reiss

Publisher

Wiley

Published

2017

Language

EN

Field

Medicine (Health Sciences)