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Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects by A. Veronica Witte; Agnes Flöel; Patrycja Stein; Markus Savli; Leonhard‐Key Mien; Wolfgang Wadsak; Christoph Spindelegger; Ulrike Moser; Martin Fink; Andreas Hahn; Markus Mitterhauser; Kurt Kletter; Siegfried Kasper; Rupert Lanzenberger is a Neuroscience article available to read on EtoBox.
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## Abstract __Objectives__: Various studies indicate that serotonin regulates impulsivity and the inhibitory control of aggression. Aggression is also known to be modified by sex hormones, which exert influence on serotonergic neurotransmission. The present study aimed to elucidate potential interactions between human aggression, the inhibitory serotonergic 5‐HT~1A~ receptor, and sex hormones. __Experimental Design__: Thirty‐three healthy volunteers (16 women, aged 26.24 ± 5.5 yr) completed a validated questionnaire incorporating five dimensions of aggression. Subsequently, all subjects underwent positron emission tomography with the radioligand [carbonyl‐^11^C]WAY‐100635 to quantify 5‐HT~1A~ binding potentials (BP~ND~s) in the prefrontal cortex, limbic areas, and midbrain. Also, plasma levels of testosterone, 17ß‐estradiol and sex hormone‐binding globulin (SHBG) were measured. Relations between aggression scores, regional 5‐HT~1A~ BP~ND~s, and hormone levels were analyzed using correlations, multivariate analyses of variance, and linear regressions. __Principal Observations__: Statistical analyses revealed higher 5‐HT~1A~ receptor BP~ND~s in subjects exhibiting higher aggression s
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- Author
- A. Veronica Witte; Agnes Flöel; Patrycja Stein; Markus Savli; Leonhard‐Key Mien; Wolfgang Wadsak; Christoph Spindelegger; Ulrike Moser; Martin Fink; Andreas Hahn; Markus Mitterhauser; Kurt Kletter; Siegfried Kasper; Rupert Lanzenberger
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)