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Nattokinase Improves Blood Flow by Inhibiting Platelet Aggregation and Thrombus Formation by Ja-Young Jang; Tae-Su Kim; Jingmei Cai; Jihyun Kim; Youngeun Kim; Kyungha Shin; Kwang Sei Kim; Sung Kyeong Park; Sung-Pyo Lee; Ehn-Kyoung Choi; Man Hee Rhee; Yun-Bae Kim is a Social Sciences article available to read on EtoBox.
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The effects of nattokinase on the in vitro platelet aggregation and in vivo thrombosis were investigated in comparison with aspirin. Rabbit platelet-rich plasma was incubated with nattokinase and aggregation inducers collagen and thrombin, and the platelet aggregation rate was analyzed. Nattokinase significantly inhibited both the collagen-and thrombin-induced platelet aggregations. Nattokinase also reduced thromboxane B 2 formation from collagen-activated platelets in a concentration-dependent manner. Rats were orally administered with nattokinase for 1 week, and their carotid arteries were exposed. Arterial thrombosis was induced by applying 35% FeCl 3 -soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Nattokinase delayed the FeCl 3 -induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 160 mg/kg. In addition, a high dose (500 mg/kg) of nattokinase fully prevented the occlusion, as achieved with aspirin (30 mg/kg). The results indicate that nattokinase extracted from fermented soybean inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial w
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It is typically read by researchers, students, and practitioners in Social Sciences.
- Author
- Ja-Young Jang; Tae-Su Kim; Jingmei Cai; Jihyun Kim; Youngeun Kim; Kyungha Shin; Kwang Sei Kim; Sung Kyeong Park; Sung-Pyo Lee; Ehn-Kyoung Choi; Man Hee Rhee; Yun-Bae Kim
- Publisher
- Springer Science and Business Media LLC
- Published
- 2013
- Language
- EN
- Field
- Social Sciences