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Defibrillation Depends on Conductivity Fluctuations and the Degree of Disorganization in Reentry Patterns by GERNOT PLANK; L. JOSHUA LEON; SHANE KIMBER; EDWARD J. VIGMOND is a Medicine article available to read on EtoBox.

What is Defibrillation Depends on Conductivity Fluctuations and the Degree of Disorganization in Reentry Patterns about?

__Introduction:__ Cardiac fibrillation is the deterioration of the heart's normally well‐organized activity into one or more meandering spiral waves, which subsequently break up into many meandering wave fronts. Delivery of an electric shock (defibrillation) is the only effective way of restoring the normal rhythm. This study focuses on examining whether higher degrees of disorganization requires higher shock strengths to defibrillate and whether microscopic conductivity fluctuations favor shock success. __Methods and Results:__ We developed a three‐dimensional computer bidomain model of a block of cardiac tissue with straight fibers immersed in a conductive bath. The membrane behavior was described by the Courtemanche human atrial action potential model incorporating electroporation and an acetylcholine‐ (ACh) dependent potassium current. Intracellular conductivities were varied stochastically around nominal values with variations of up to 50%. A single rotor reentry was initiated and, by adjusting the spatial ACh variation, the level of organization could be controlled. The single rotor could be stabilized or spiral wave breakup could be provoked leading to fibrillatory‐like acti

Who reads Defibrillation Depends on Conductivity Fluctuations and the Degree of Disorganization in Reentry Patterns?

Author

GERNOT PLANK; L. JOSHUA LEON; SHANE KIMBER; EDWARD J. VIGMOND

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Futura Publishing Company, Inc; Blackwell Publishing Inc.; Wiley (ISSN 1540-8167)

Published

2005

Language

EN

Field

Medicine (Health Sciences)