Can I read MK-7 and Its Effects on Bone Quality and Strength on EtoBox?

MK-7 and Its Effects on Bone Quality and Strength by Sato, Toshiro; Inaba, Naoko; Yamashita, Takatoshi is a Medicine article available to read on EtoBox.

What is MK-7 and Its Effects on Bone Quality and Strength about?

Vitamin K acts as a cofactor and is required for post-translational γ-carboxylation of vitamin K-dependent proteins (VKDP). The current recommended daily intake (RDI) of vitamin K in most countries has been established based on normal coagulation requirements. Vitamin K1 and menaquinone (MK)-4 has been shown to decrease osteocalcin (OC) γ-carboxylation at RDI levels. Among the several vitamin K homologs, only MK-7 (vitamin K2) can promote γ-carboxylation of extrahepatic VKDPs, OC, and the matrix Gla protein at a nutritional dose around RDI. MK-7 has higher efficacy due to its higher bioavailability and longer half-life than other vitamin K homologs. As vitamin K1, MK-4, and MK-7 have distinct bioactivities, their RDIs should be established based on their relative activities. MK-7 increases bone mineral density and promotes bone quality and strength. Collagen production, and thus, bone quality may be affected by MK-7 or MK-4 converted from MK-7. In this review, we comprehensively discuss the various properties of MK-7.

Who reads MK-7 and Its Effects on Bone Quality and Strength?

Author

Sato, Toshiro; Inaba, Naoko; Yamashita, Takatoshi

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2009-; Publons; Research Square (ISSN 2072-6643)

Published

2020

Language

EN

Field

Medicine (Health Sciences)