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Fine Structure of the Testis and Epididymis of Rats Treated with Cyproterone Acetate by C. J. Flickinger; C. K. Loving is a Medicine article available to read on EtoBox.

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## Abstract Adult male rats were administered the antiandrogen, cyproterone acetate, for 4, 8 or 12 weeks, and the histology and fine structure of the testis and several parts of the epididymis were studied. After treatment for 8 or 12 weeks, the testes of treated animals displayed a great reduction in the abundance of late spermatids. Necrotic cells, many of which were identified as cap‐phase spermatids, were present in the seminiferous epithelium. Sertoli cells contained many large lipid droplets and lysosome‐like structures with a content of cellular debris, including parts of spermatids. Leydig cells of treated rats were smaller than those of control animals at all the intervals studied. Sperm were absent from the lumen of the middle segment, or caput epididymidis, of severely affected specimens. In the terminal segment, or cauda epididymidis, the microscopic appearance varied in different regions. In the proximal part of the cauda epididymidis, the lumen was usually clear of sperm. The epithelium was tall and the light cells were very large and distended with many dense bodies resembling lysosomes. In contrast, in the distal part of the cauda epididymidis, the lumen was filled

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Author

C. J. Flickinger; C. K. Loving

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0002-9106)

Published

1976

Language

EN

Field

Medicine (Health Sciences)