Opening book details…
Can I read Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories on EtoBox?
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories by Marisol Lavertu-Jolin; Bidisha Chattopadhyaya; Pegah Chehrazi; Denise Carrier; Florian Wünnemann; Séverine Leclerc; Félix Dumouchel; Derek Robertson; Hicham Affia; Kamal Saba; Vijaya Gopal; Anant Bahadur Patel; Gregor Andelfinger; Graçiela Pineyro; Graziella Di Cristo is a Neuroscience article available to read on EtoBox.
What is Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories about?
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear memory recovery in adults, but it is highly effective in juvenile rodents. Maturation of GABAergic circuits, in particular of parvalbumin-positive (PV^+^) cells, restricts plasticity in the adult brain, thus reducing PV^+^ cell maturation could promote the suppression of fear memories following extinction training in adults. Epigenetic modifications such as histone acetylation control gene accessibility for transcription and help couple synaptic activity to changes in gene expression. Histone deacetylase 2 (Hdac2), in particular, restrains both structural and functional synaptic plasticity. However, whether and how Hdac2 controls the maturation of postnatal PV^+^ cells is not well understood. Here, we show that PV^+^- cell specific __Hdac2__ deletion limits spontaneous fear memory recovery in adult mice, while enhancing PV^+^ cell bouton remodeling and reducing perineuronal net aggregation around PV^+^ cells in prefrontal cortex and basolateral amygdala. Prefrontal cortex PV^+^
Who reads Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Marisol Lavertu-Jolin; Bidisha Chattopadhyaya; Pegah Chehrazi; Denise Carrier; Florian Wünnemann; Séverine Leclerc; Félix Dumouchel; Derek Robertson; Hicham Affia; Kamal Saba; Vijaya Gopal; Anant Bahadur Patel; Gregor Andelfinger; Graçiela Pineyro; Graziella Di Cristo
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)