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Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible by Bonilla, Cesar A.; Crossa, Aldo; Jave, Hector O.; Mitnick, Carole D.; Jamanca, Ronal B.; Herrera, Cesar; Asencios, Luis; Mendoza, Alberto; Bayona, Jaime; Zignol, Matteo; Jaramillo, Ernesto; Marais, Ben is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible about?
## Aim To describe the incidence of extensive drug-resistant tuberculosis (XDR-TB) reported in the Peruvian National multidrug-resistant tuberculosis (MDR-TB) registry over a period of more than ten years and present the treatment outcomes for a cohort of these patients. ## Methods From the Peruvian MDR-TB registry we extracted all entries that were approved for second-line anti-TB treatment between January 1997 and June of 2007 and that had Drug Susceptibility Test (DST) results indicating resistance to both rifampicin and isoniazid (i.e. MDR-TB) in addition to results for at least one fluoroquinolone and one second-line injectable (amikacin, capreomycin and kanamycin). ## Results Of 1,989 confirmed MDR-TB cases with second-line DSTs, 119(6.0%) XDR-TB cases were detected between January 1997 and June of 2007. Lima and its metropolitan area account for 91% of cases, a distribution statistically similar to that of MDR-TB. A total of 43 XDR-TB cases were included in the cohort analysis, 37 of them received ITR. Of these, 17(46%) were cured, 8(22%) died and 11(30%) either failed or defaulted treatment. Of the 14 XDR-TB patients diagnosed as such before ITR treatment initiation, 10 (71
Who reads Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bonilla, Cesar A.; Crossa, Aldo; Jave, Hector O.; Mitnick, Carole D.; Jamanca, Ronal B.; Herrera, Cesar; Asencios, Luis; Mendoza, Alberto; Bayona, Jaime; Zignol, Matteo; Jaramillo, Ernesto; Marais, Ben
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science; Publons; ScienceOpen; Public Library of Science (PLoS) (ISSN 1932-6203)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)