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Recombinant Human Erythropoietin Stimulates Production of Interleukin 2 by Whole Blood Cell Cultures of Hemodialysis Patients by Ewa Bryl; Jolanta Myśliwska; Alicja Dębska-Ślizień; Piotr Trzonkowski; Dominik Rachoń; Barbara Bułło; Zbigniew Zdrojewski; Andrzej Myśliwski; Bolesław Rutkowski is a Medicine article available to read on EtoBox.

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The impairment of function of human T lymphocytes, leading to an inappropriate cytokine production, is partially responsible for defective immunological response in hemodialysis patients (HD). Recent data suggest that recombinant human erythropoietin (rhEPO) may exert immunological effects. The aim of this study was to find out whether rhEPO treatment of the HD patients may have an effect on the interleukin 2 (IL-2) production by their whole blood cell cultures. The study was carried out in 10 HD patients receiving rhEPO for 6 months. Com-pared with the levels seen before the treatment, the concentration of IL-2 increased in the phytohemagglutininstimulated whole blood cell cultures of 7 of 10 patients under study. Addition of rhEPO in vitro to the whole blood cell cultures of the HD patients before implementation of erythropoietin confirmed that rhEPO is able to directly stimulate IL-2 production. Our studies show that the therapy with rhEPO affects IL-2 secretion.

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Author

Ewa Bryl; Jolanta Myśliwska; Alicja Dębska-Ślizień; Piotr Trzonkowski; Dominik Rachoń; Barbara Bułło; Zbigniew Zdrojewski; Andrzej Myśliwski; Bolesław Rutkowski

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0160-564X)

Published

1999

Language

EN

Field

Medicine (Health Sciences)