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Effects of estrogens and antiestrogens on gene expression of fathead minnow ( Pimephales promelas ) early life stages by Sonia M. Johns; Nancy D. Denslow; Michael D. Kane; Karen H. Watanabe; Edward F. Orlando; Maria S. Sepúlveda is a Environmental Science article available to read on EtoBox.

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Endocrine disrupting chemicals (EDCs) are known to contaminate aquatic environments and alter the growth and reproduction of organisms. The objective of this study was to evaluate the sensitivity and utility of fathead minnow (Pimephales promelas) early life-stages as a model to measure effects of estrogenic and antiestrogenic EDCs on physiological and gene expression endpoints relative to growth and reproduction. Embryos (<24-h postfertilization, hpf) were exposed to a potent estrogen (17α-ethinyl estradiol, EE(2) , 2, 10, and 50 ng L(-1)); a weak estrogen (mycotoxin zearalenone, ZEAR, same concentrations as above); an antiestrogen (ZM 189, 154; 40, 250, and 1000 ng L(-1)); and to mixtures of EE(2) and ZM until swim-up stage (∼170 hpf). Exposure to all concentrations of ZEAR and to the lowest concentration of ZM resulted in increased body sizes, whereas high concentrations of EE(2) decreased body sizes. There was a significant increase in the frequency of abnormalities (mostly edema) in larvae exposed to all concentrations of EE(2), and high ZEAR, and EE(2) + ZM mixture groups. Expression of growth hormone was upregulated by most of the conditions tested. Exposure to 50 ng L(-1) Z

Who reads Effects of estrogens and antiestrogens on gene expression of fathead minnow ( Pimephales promelas ) early life stages?

Author

Sonia M. Johns; Nancy D. Denslow; Michael D. Kane; Karen H. Watanabe; Edward F. Orlando; Maria S. Sepúlveda

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)

Published

2011

Language

EN

Field

Environmental Science (Physical Sciences)