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Can I read Ferroptosis Contributes to Isoflurane-induced Neurotoxicity and Learning and Memory Impairment on EtoBox?
Ferroptosis Contributes to Isoflurane-induced Neurotoxicity and Learning and Memory Impairment by Liu, Pengfei (author);Yuan, Jing (author);Feng, Yetong (author);Chen, Xin (author);Wang, Guangsuo (author);Zhao, Lei (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Ferroptosis Contributes to Isoflurane-induced Neurotoxicity and Learning and Memory Impairment about?
Ferroptosis is a novel type of programmed cell death, which is different from apoptosis and autophagic cell death. Recently, ferroptosis has been indicated to contribute to the in vitro neurotoxicity induced by isoflurane, which is one of the most common anesthetics in clinic. However, the in vivo position of ferroptosis in isoflurane-induced neurotoxicity as well as learning and memory impairment remains unclear. In this study, we mainly explored the relationship between ferroptosis and isoflurane-induced learning and memory, as well as the therapeutic methods in mouse model. Our results indicated that isoflurane induced the ferroptosis in a dose-dependent and time-dependent manner in hippocampus, the organ related with learning and memory ability. In addition, the activity of cytochrome c oxidase/Complex IV in mitochondrial electron transport chain (ETC) was increased by isoflurane, which might further contributed to cysteine deprivation-induced ferroptosis caused by isoflurane exposure. More importantly, isoflurane-induced ferroptosis could be rescued by both ferroptosis inhibitor (ferrostatin-1) and mitochondria activator (dimethyl fumarate), which also showed effective therape
Who reads Ferroptosis Contributes to Isoflurane-induced Neurotoxicity and Learning and Memory Impairment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Liu, Pengfei (author);Yuan, Jing (author);Feng, Yetong (author);Chen, Xin (author);Wang, Guangsuo (author);Zhao, Lei (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)