About this Biochemistry, Genetics and Molecular Biology article
Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis by Kevin G Liu; Millard H Lambert; Lisa M Leesnitzer; William Oliver Jr.; Ronda J Ott; Kelli D Plunket; Ludwig W Stuart; Peter J Brown; Timothy M Willson; Daniel D Sternbach is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPARg/d dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kevin G Liu; Millard H Lambert; Lisa M Leesnitzer; William Oliver Jr.; Ronda J Ott; Kelli D Plunket; Ludwig W Stuart; Peter J Brown; Timothy M Willson; Daniel D Sternbach
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)