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Synthesis and Antitumor Activity of Simplified Ecteinascidin–saframycin Analogs by Zhan-Zhu Liu; Ye Wang; Ye-Feng Tang; Shi-Zhi Chen; Xiao-Guang Chen; Hong-Yan Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and Antitumor Activity of Simplified Ecteinascidin–saframycin Analogs about?
Two series of simplified analogs of the ecteinascidin-saframycin type alkaloids were prepared from L L-DOPA. Their in vitro antitumor activity was tested against three human cancer cell lines (HCT-8 colon carcinoma, Bel-7402 liver carcinoma, and BGC-823 gastric carcinoma). Among these compounds, the ester analogs have stronger activities than those of amide analogs in general. Among them, 1-naphthalene carboxylate ester analog 31 has the strongest activity against BGC-823 cells.
Who reads Synthesis and Antitumor Activity of Simplified Ecteinascidin–saframycin Analogs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhan-Zhu Liu; Ye Wang; Ye-Feng Tang; Shi-Zhi Chen; Xiao-Guang Chen; Hong-Yan Li
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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