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Interleukins 1 Beta and 6 Induce Functional Alteration of Rat Colonic Motility: an in Vitro Study by L. Natale; A. L. Piepoli; M. A. De Salvia; G. De Salvatore; C. I. Mitolo; A. Marzullo; P. Portincasa; A. Moschetta; G. Palasciano; D. Mitolo‐Chieppa is a Medicine article available to read on EtoBox.

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## Abstract Background In rodents, interleukins administration induces intestinal changes similar to those found in inflammatory bowel disease. We investigated the effects of __in vivo__ subchronic treatment with IL‐1 beta and IL‐6 on rat colonic mucosa and circular smooth muscle. Materials and method We evaluated transmucosal electrical parameters (Ussing chambers) and early changes of __in vitro__ direct contractility induced by carbachol and tachykinins. Alterations in excitatory and inhibitory neurotransmission were studied with electrical field stimulation (EFS). Results Treatment with interleukins induces inflammation proved by fever, early signs of colonic histological damage and changes in mucosal ion transport. Concentration response‐curve to carbachol was significantly lower in treated rats (__P__ < 0·02) with significant difference in E~max~ between control (1·67 ± 0·17 g) and treated preparations (1·20 ± 0·13 g) (__P__ < 0·05). Concentration response‐curve to NK~2~ agonist was significantly lower in the treated rats (__P__ < 0·005) with a significant difference in E~max~ between the control (0·26 ± 0·04 g) and treated preparations (0·12 ± 0·02 g) (__P__ < 0·02). None of

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Author

L. Natale; A. L. Piepoli; M. A. De Salvia; G. De Salvatore; C. I. Mitolo; A. Marzullo; P. Portincasa; A. Moschetta; G. Palasciano; D. Mitolo‐Chieppa

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)

Published

2003

Language

EN

Field

Medicine (Health Sciences)