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Can I read Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling on EtoBox?
Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling by Ge, Chenxu (author);Tan, Jun (author);Lou, Deshuai (author);Zhu, Liancai (author);Zhong, Zixuan (author);Dai, Xianling (author);Sun, Yan (author);Kuang, Qin (author);Zhao, Junjie (author);Wang, Longyan (author);Liu, Jin (author);Wang, Bochu (author);Xu, Minxuan (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling about?
Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with various biological functions. However, the effects of Mul on liver fibrosis have not been addressed, and thus were investigated in our present study, as well as the underlying mechanisms. Here, we found that Mul administration significantly ameliorated carbon tetrachloride (CCl 4 )-induced liver injury and dysfunction in mice. Furthermore, CCl 4 -triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor β1 (TGF-β1)/SMAD2/3 signaling pathway. Additionally, Mul treatments strongly restrained the hepatic inflammation in CCl 4 -challenged mice via blocking nuclear factor-κB (NF-κB) signaling. Importantly, we found that Mul markedly increased liver TRIM31 expression in CCl 4 -treated mice, accompanied with the inactivation of NOD-like receptor protein 3 (NLRP3) inflammasome. CCl 4 -triggered hepatic oxidative stress was also efficiently mitigated by Mul consumption via improving nuclear factor E2-related factor 2 (Nrf2) activation. Our in vitro studies confirmed that Mul reduced the activation of human a
Who reads Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ge, Chenxu (author);Tan, Jun (author);Lou, Deshuai (author);Zhu, Liancai (author);Zhong, Zixuan (author);Dai, Xianling (author);Sun, Yan (author);Kuang, Qin (author);Zhao, Junjie (author);Wang, Longyan (author);Liu, Jin (author);Wang, Bochu (author);Xu, Minxuan (author)
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)