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Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice by Jingwei Liu; Junchao Shi; Rebecca Hernandez; Xiuchun Li; Pranav Konchadi; Yuma Miyake; Qi Chen; Tong Zhou; Changcheng Zhou is a Environmental Science article available to read on EtoBox.
What is Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice about?
Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is associated with the increased risk of many chronic diseases. For example, phthalate exposure is associated with cardiometabolic mortality in humans, with societal costs ~ $39 billion/year or more. We recently demonstrated that several widely used plastic-associated EDCs increase cardiometabolic disease in appropriate mouse models. In addition to affecting adult health, parental exposure to EDCs has also been shown to cause metabolic disorders, including obesity and diabetes, in the offspring. While most studies have focused on the impact of maternal EDC exposure on the offspring’s health, little is known about the effects of paternal EDC exposure. In the current study, we investigated the adverse impact of paternal exposure to a ubiquitous but understudied phthalate, dicyclohexyl phthalate (DCHP) on the metabolic health of F1 and F2 offspring in mice. Paternal DCHP exposure led to exacerbated insulin resistance and impaired insulin signaling in F1 offspring without affecting diet-induced obesity. We previously showed that sperm small non-coding RNAs including tRNA-derived small RNAs (tsRNAs) and rRNA
Who reads Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jingwei Liu; Junchao Shi; Rebecca Hernandez; Xiuchun Li; Pranav Konchadi; Yuma Miyake; Qi Chen; Tong Zhou; Changcheng Zhou
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)