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Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II) by Aparna Jain; M. C. Martin; Nazneen Parveen; N. U. Khan; J. H. Parish; S. M. Hadi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II) about?

DNA strand scission reactions of flavonoids in the presence of Cu(II) have been extended by using flavonoids with a variety of patterns of hydroxyl substitution. In particular we have examined for the first time a flavonoid (7,8-dihydroxyflavone) that lacks the possibility of forming a complex involving the oxygen at position 4. By comparing the reactivities of several flavonoids, including data from the literature, we draw generalizations for the correlation of structure and activity and present evidence for at least three different modes of action of flavonoids as genotoxic agents.

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Author

Aparna Jain; M. C. Martin; Nazneen Parveen; N. U. Khan; J. H. Parish; S. M. Hadi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

1999

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)