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Can I read Long‐term efficacy and safety of apremilast in psoriatic arthritis: Focus on skin manifestations and special populations on EtoBox?
Long‐term efficacy and safety of apremilast in psoriatic arthritis: Focus on skin manifestations and special populations by Anna Balato; Elena Campione; Teresa Cirillo; Giovanna Malara; Caterina Trifirò; Luca Bianchi; Gabriella Fabbrocini is a Medicine article available to read on EtoBox.
What is Long‐term efficacy and safety of apremilast in psoriatic arthritis: Focus on skin manifestations and special populations about?
Few real-life studies evaluated long-term apremilast therapy in the variable spectrum of clinical-anamnestic features which can be found in psoriatic arthritis (PsA) patients. This real-life retrospective observational study aimed to assess long-term efficacy, safety, and tolerability of apremilast among patients with PsA and concomitant cutaneous psoriasis. A stratified analysis was performed on special populations, defined as (a) number (≤1 vs >2) of comorbidities, presence or absence of: (b) history of malignancy, and (c) previous exposure to biologics. Patients attending three Italian University and Hospital centers, who received at least one dose of apremilast and had at least one follow-up visit were included. Ninety-six patients with PsA were identified. Psoriasis Area and Severity Index (PASI), Body Surface Area, 28-joint Disease Activity Score, and Dermatology Life Quality Index scores improved during treatment, already at week 4, relative to baseline. More than 2 comorbidities, history of malignancy and previous biologic treatment negatively influenced PASI responses. At least one adverse event was experienced by 56/96 patients, and 11/56 events required drug withdrawal.
Who reads Long‐term efficacy and safety of apremilast in psoriatic arthritis: Focus on skin manifestations and special populations?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anna Balato; Elena Campione; Teresa Cirillo; Giovanna Malara; Caterina Trifirò; Luca Bianchi; Gabriella Fabbrocini
- Publisher
- Hindawi Limited
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)