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Extracts from Argentinian native plants reverse fluconazole resistance in Candida species by inhibiting the efflux transporters Mdr1 and Cdr1 by Florimar Gil; Jerónimo Laiolo; Brayan Bayona-Pacheco; Richard D. Cannon; Antonio Ferreira-Pereira; María Cecilia Carpinella is a Medicine article available to read on EtoBox.
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## Background: The development of multidrug resistance (mdr) associated with the overexpression of the efflux transporters mdr1 and cdr1 in candida species impedes antifungal therapies. the urgent need for novel agents able to inhibit the function of both pumps, led us to evaluate this property in 137 extracts obtained from argentinian plants. ## Methods: The ability of the extracts to reverse efflux pump-mediated mdr was determined with an agar chemosensitization assay using fluconazole (fcz) resistant mdr1- and cdr1-overexpressing clinical isolates of candida albicans and candida glabrata as well as saccharomyces cerevisiae strains selectively expressing mdr1 (ad/camdr1) or cdr1 (ad/cacdr1). the resistance-reversing activity of the most potent extracts was further confirmed using a nile red accumulation assay. ## Results: Fifteen plant extracts overcame the fcz resistance of candida albicans 1114, which overexpresses camdr1 and cacdr1, and ad/camdr1, with those from acalypha communis and solanum atriplicifolium being the most effective showing 4- to 16-fold reversal of resistance at concentrations ≥ 25 μg/ml. both extracts, and to a lesser extent that from pterocaulon alopecuroid
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- Author
- Florimar Gil; Jerónimo Laiolo; Brayan Bayona-Pacheco; Richard D. Cannon; Antonio Ferreira-Pereira; María Cecilia Carpinella
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)