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ABO incompatible stem cell transplantation in children does not influence outcome by A.M. Helming; A. Brand; R. Wolterbeek; M.J.D. van Tol; R.M. Egeler; L.M. Ball is a Medicine article available to read on EtoBox.

What is ABO incompatible stem cell transplantation in children does not influence outcome about?

## Abstract ## Background Although delayed red cell engraftment and/or hemolysis have been thoroughly documented in association with ABO incompatibility between donor and recipient in patients undergoing hematopoietic stem cell transplantation (HSCT), there are no studies defining the general, long term clinical outcome in a large group of pediatric patients. ## Methods We undertook a retrospective single center analysis of children undergoing pediatric allogeneic stem cell transplantation to determine the influence of ABO donor/recipient incompatibility. Outcome was analyzed according to donor type and included survival, graft versus host disease (GvHD), relapse, days of infection, antibiotic use, transfusion requirement and duration of hospital stay. ## Results Two hundred and sixteen children (136 males; 80 females, aged 0–19) transplanted between January 1992 and December 2003 were included in the study. Indications for transplantation were hematological malignancies (n = 179) and aplastic conditions (n = 37). ABO compatibility was documented in 121 donor/recipient pairs. ABO incompatibility was documented in 95 donor/recipient pairs with 40 major, 40 minor and 15 bi‐directiona

Who reads ABO incompatible stem cell transplantation in children does not influence outcome?

Author

A.M. Helming; A. Brand; R. Wolterbeek; M.J.D. van Tol; R.M. Egeler; L.M. Ball

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2006

Language

EN

Field

Medicine (Health Sciences)