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Can I read COVID-19 and the liver: an adverse outcome pathway perspective on EtoBox?
COVID-19 and the liver: an adverse outcome pathway perspective by Mathieu Vinken is a Environmental Science article available to read on EtoBox.
What is COVID-19 and the liver: an adverse outcome pathway perspective about?
Liver damage is observed in up to half of hospitalized COVID-19 patients and can result either from actions of SARS-CoV-2 as such or from pharmacological treatment. The present paper introduces an adverse outcome pathway construct that mechanistically describes the pathways induced by SARS-CoV-2 leading to liver injury. This can be caused by direct binding of the virus and local actions in cholangiocytes, but may also indirectly result from the general state of hypoxia and systemic inflammation in COVID-19 patients. Further research is urgently needed to fill remaining knowledge gaps. This will be anticipated to create a solid basis for future and more targeted development of vaccines and, in particular, therapies.
Who reads COVID-19 and the liver: an adverse outcome pathway perspective?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Mathieu Vinken
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Environmental Science (Life Sciences)