Can I read Exploring the Sulfate Patterns of Chondroitin Sulfate/dermatan Sulfate and Keratan Sulfate in Human Pancreatic Cancer on EtoBox?

Exploring the Sulfate Patterns of Chondroitin Sulfate/dermatan Sulfate and Keratan Sulfate in Human Pancreatic Cancer by Qiang Ren; Jian Wang; Chao Liu; Ling-xin Meng; Rui-kun Qian; Hui-jie Gao; Wei Qin; Cai-ju Zhou; Sen Qiao; Hui-yun Wang; Li-tao Zhang; Yun-tao Zhang is a Chemistry article available to read on EtoBox.

What is Exploring the Sulfate Patterns of Chondroitin Sulfate/dermatan Sulfate and Keratan Sulfate in Human Pancreatic Cancer about?

This study was designed to explore the sulfation patterns of chondroitin sulfate (CS)/dermatan sulfate (DS), and keratan sulfate (KS) and the expression of carbohydrate sulfotransferases (CHSTs) in 26 pancreatic tumor and normal tissues. CS/DS and KS profiles were simultaneously determined. Pancreatic tumor tissues exhibited increased ΔDi-0S, ΔDi-4S, and ΔDi-6S levels, with absolute ΔDi-4S content being highest, followed by ΔDi-6S. However, as for the contents of KS-6S and KS-6S,6'S, there were no significant regular change. The expression levels of CHST1 and CHST4 were 37 and 15 times higher than those in normal tissues. PCA and OPLS-DA revealed that ΔDi-4S and ΔDi-6S levels could be reliably used to differentiate between healthy and cancerous tissues. The up-regulation of CHST3, CHST12, CHST13, and CHST15 was directly correlated with C-4 and C-6 sulfation. These data provide a foundation for future studies of the role of ΔDi-4S and ΔDi-6S in the progression of pancreatic cancer.

Who reads Exploring the Sulfate Patterns of Chondroitin Sulfate/dermatan Sulfate and Keratan Sulfate in Human Pancreatic Cancer?

Author

Qiang Ren; Jian Wang; Chao Liu; Ling-xin Meng; Rui-kun Qian; Hui-jie Gao; Wei Qin; Cai-ju Zhou; Sen Qiao; Hui-yun Wang; Li-tao Zhang; Yun-tao Zhang

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)