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Isolated ACTH deficiency following immunization with the BNT162b2 SARS-CoV-2 vaccine: a case report by Shuhei Morita; Tomoya Tsuji; Shohei Kishimoto; Shinsuke Uraki; Ken Takeshima; Hiroshi Iwakura; Hiroto Furuta; Masahiro Nishi; Hidefumi Inaba; Taka-aki Matsuoka is a Medicine article available to read on EtoBox.
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## Abstract ## Background The global COVID-19 pandemic requires urgent development of new vaccines. Endocrinological adverse effects following the new mRNA vaccine against COVID-19 have been reported in several cases. Specific to the involvement of pituitary function; however, only a single case with hypophysis has been reported. This is the first case of isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) following mRNA vaccination against COVID-19. ## Case presentation A healthy 31-year-old man received the BNT162b2 SARS-CoV-2 mRNA vaccine. The first injection was uneventful. One day after the second injection, he noticed general fatigue and fever. In the following several days, he additionally developed headaches, nausea, and diarrhea. Four days after the vaccine injection, he visited a hospital with worsening of these symptoms. Physical examination revealed slight disorientation but no other deficits. Laboratory tests revealed hyponatremia, hypoglycemia, and extremely low plasma ACTH and serum cortisol levels (ACTH < 1.5 pg/ml, cortisol 1.6 μg/dl). He was diagnosed with adrenal crisis and was emergently treated with hydrocortisone. The symptoms responded well and he re
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- Author
- Shuhei Morita; Tomoya Tsuji; Shohei Kishimoto; Shinsuke Uraki; Ken Takeshima; Hiroshi Iwakura; Hiroto Furuta; Masahiro Nishi; Hidefumi Inaba; Taka-aki Matsuoka
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)