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This document reviews approaches to increase the effectiveness of temozolomide (TMZ) for treating glioblastoma (GBM). GBM is an aggressive brain cancer with poor survival rates. The standard treatment is surgery, radiation, and TMZ chemotherapy, but tumors often become resistant. The review discusses mechanisms of TMZ resistance, like DNA repair pathways and drug transporters. It also analyzes strategies studied to overcome resistance, such as using additional drugs to sensitize tumors or improving drug del

Author

Wadee

Language

EN