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Involvement of NLK and Sox11 in neural induction in Xenopus development by Junko Hyodo‐Miura; Seiichi Urushiyama; Shin‐ichi Nagai; Michiru Nishita; Naoto Ueno; Hiroshi Shibuya is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Involvement of NLK and Sox11 in neural induction in Xenopus development about?
## Abstract **__Background__ :** The Wnt signal transduction pathway regulates various aspects of embryonal development and has been implicated in promoting cancer. Signalling by Wnts leads to the stabilization of cytosolic β‐catenin, which then associates with TCF transcription factors to regulate expression of Wnt‐target genes. The Wnt pathway is further subject to cross‐regulation at various levels by other components. **__Results__:** Recent evidence suggests that a specific MAP kinase pathway involving the MAP kinase kinase kinase TAK1 and the MAP kinase NLK counteract Wnt signalling. In particular, it has been shown that TAK1 activates NLK, which phosphorylates TCFs bound to β‐catenin. This phosphorylation down‐regulates the DNA‐binding activity of a TCF‐4/β‐catenin complex, and blocks activation of their target genes. To investigate the role of NLK in __Xenopus__ development, we isolated xNLK, a __Xenopus__ homologue of NLK. Our findings indicate that xNLK is expressed in neural tissues and induces the anterior‐neural marker gene, Otx‐2. Moreover, xSox11, which is induced by the expression of Chordin, co‐operates with xNLK to induce neural development. These molecules also i
Who reads Involvement of NLK and Sox11 in neural induction in Xenopus development?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Junko Hyodo‐Miura; Seiichi Urushiyama; Shin‐ichi Nagai; Michiru Nishita; Naoto Ueno; Hiroshi Shibuya
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)