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Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy by Jinghua Sun; Yahong Han; Jie Dong; Shuxin Lv; Ruiping Zhang is a Engineering article available to read on EtoBox.

What is Melanin/melanin-like nanoparticles: As a naturally active platform for imaging-guided disease therapy about?

The development of biocompatible and efficient nanoplatforms that combine diagnostic and therapeutic functions is of great importance for precise disease treatment. Melanin, an endogenous biopolymer present in living organisms, has attracted increasing attention as a versatile bioinspired functional platform owing to its unique physicochemical properties (e.g., high biocompatibility, strong chelation of metal ions, broadband light absorption, high drug binding properties) and inherent antioxidant, photoprotective, anti-inflammatory, and anti-tumor effects. In this review, the fundamental physicochemical properties and preparation methods of natural melanin and melanin-like nanoparticles were outlined. A systematical description of the recent progress of melanin and melanin-like nanoparticles in single, dual-, and tri-multimodal imaging-guided the visual administration and treatment of osteoarthritis, acute liver injury, acute kidney injury, acute lung injury, brain injury, periodontitis, iron overload, etc. Was then given. Finally, it concluded with a reasoned discussion of current challenges toward clinical translation and future striving directions. Therefore, this comprehensive

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Author

Jinghua Sun; Yahong Han; Jie Dong; Shuxin Lv; Ruiping Zhang

Publisher

Elsevier

Published

2023

Language

EN

Field

Engineering (Physical Sciences)