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Extracellular Vesicle Transmission of Chemoresistance to Ovarian Cancer Cells Is Associated with Hypoxia-Induced Expression of Glycolytic Pathway Proteins, and Prediction of Epithelial Ovarian Cancer Disease Recurrence by Alharbi, Mona (author);Lai, Andrew (author);Sharma, Shayna (author);Kalita-de Croft, Priyakshi (author);Godbole, Nihar (author);Campos, America (author);Guanzon, Dominic (author);Salas-Burgos, Alexis (author);Carrion, Flavio (author);Zuñiga, Felipe A. (author);Perrin, Lewis (author);He, Yaowu (author);Pejovic, Tanja (author);Winters, Carmen (author);Morgan, Terry (author);Hooper, John D. (author);Rice, Gregory E. (author);Salomon, Carlos (author) is a Medicine article available to read on EtoBox.

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## Simple Summary Ovarian cancer is one of the most lethal cancers affecting women worldwide. Its high mortality rate is often attributed to the non-specific nature of early symptoms of the disease. Developing a better understanding of the disease progression and identifying clinically useful biomarkers that aid in clinical management are requisite to reducing the mortality rate of ovarian cancer. Reduced oxygen tension (i.e., hypoxia) is not only a characteristic of solid tumors but may also enhance the metastatic capacity of tumors by inducing the release of tumor growth promoting factors. Recently, it has been proposed that small tumor-derived extracellular vesicles (sEVs) facilitate cancer progression. In this study, we established that sEVs produced under low oxygen tension induce a metabolic switch in ovarian cancer cells associated with changes in glycolytic pathway proteins that promote resistance to carboplatin. Significantly, we identified a suite of sEV-associated glycolysis pathway proteins that are present in patients with ovarian cancer that can predict disease recurrence with over 90% accuracy. ## Abstract Hypoxia is a key regulator of cancer progression and chemores

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Author

Alharbi, Mona (author);Lai, Andrew (author);Sharma, Shayna (author);Kalita-de Croft, Priyakshi (author);Godbole, Nihar (author);Campos, America (author);Guanzon, Dominic (author);Salas-Burgos, Alexis (author);Carrion, Flavio (author);Zuñiga, Felipe A. (author);Perrin, Lewis (author);He, Yaowu (author);Pejovic, Tanja (author);Winters, Carmen (author);Morgan, Terry (author);Hooper, John D. (author);Rice, Gregory E. (author);Salomon, Carlos (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)