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The role of cerebellar damage in explaining disability and cognition in multiple sclerosis phenotypes: a multiparametric MRI study by Raffaello Bonacchi; Alessandro Meani; Elisabetta Pagani; Olga Marchesi; Massimo Filippi; Maria A. Rocca is a Medicine article available to read on EtoBox.
What is The role of cerebellar damage in explaining disability and cognition in multiple sclerosis phenotypes: a multiparametric MRI study about?
## Background: Cerebellar involvement is not comprehensively studied from an mri point of view in multiple sclerosis (ms). we aimed to quantify cerebellar damage and identify predictors of physical disability and cognitive dysfunction in ms patients, and to characterize patients with cerebellar disability. ## Methods: In this prospective study, 164 (89 relapsing-remitting and 75 progressive) ms patients and 53 healthy controls were enrolled. subjects underwent 3t mri with sequences for assessing lesions and atrophy in cerebellum, supratentorial brain, brainstem and cervical cord. cerebellar peduncle diffusion-tensor metrics were also derived. random forest models identified mri predictors of expanded disability status scale (edss) score and cognition z-score. hierarchical clustering was applied on mri metrics in patients with cerebellar disability. ## Results: In ms patients, predictors of higher edss score (out-of-bag-r = 0.83) were: lower cord grey matter (gm) and global areas, brain volume, gm volume (gmv), cortical gmv, cerebellum lobules i-iv and vermis gmv; and higher cord gm and brainstem lesion volume (lv). predictors of lower cognition z-score (out-of-bag-r = 0.25) were: h
Who reads The role of cerebellar damage in explaining disability and cognition in multiple sclerosis phenotypes: a multiparametric MRI study?
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- Author
- Raffaello Bonacchi; Alessandro Meani; Elisabetta Pagani; Olga Marchesi; Massimo Filippi; Maria A. Rocca
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)